Anti-FERMT2 Antibody
Catalog No : IGX-45632
262.00€
188.00€
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| Description | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. | ||
|---|---|---|---|
| Other names | Fermitin family homolog 2, Kindlin-2, Mitogen-inducible gene 2 protein, MIG-2, Pleckstrin homology domain-containing family C member 1, PH domain-containing family C member 1, FERMT2, KIND2 MIG2 PLEKHC1 | ||
| Cellular localization | Plasma Membrane, Lamellipodium Membrane, Peripheral Membrane, , Cytoskeleton, Stress Fiber, Nucleus, Cytoplasm, Cell Cortex, Focal Adhesion, Membrane, I Band, Cell Surface | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q96AC1 | ||
| Product name | Anti-FERMT2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45632 | ||
| Supplier’s Catalog No | IGX-45632 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:500-1:1000, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Fermitin family homolog 2 protein (155-232AA) | ||
| Specificity | FERMT2 antibody detects endogenous level of FERMT2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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