Anti-ATP6AP2 / Renin receptor Antibody
Catalog No : IGX-45898
262.00€
188.00€
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| Description | Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump (PMID:12045255, PMID:29127204). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (PMID:12045255). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (PMID:12045255). Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal system, plays a role in many neuronal processes including synapse morphology and synaptic transmission . | ||
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| Other names | Renin receptor, ATPase H,+,-transporting lysosomal accessory protein 2, ATPase H,+,-transporting lysosomal-interacting protein 2, ER-localized type I transmembrane adaptor, Embryonic liver differentiation factor 10, N14F, Renin/prorenin receptor, Vacuolar ATP synthase membrane sector-associated protein M8-9, ATP6M8-9, V-ATPase M8.9 subunit, ATP6AP2, ATP6IP2 CAPER ELDF10 | ||
| Cellular localization | Lysosome Membrane, Plasma Membrane, Dendritic Spine Membrane, Endoplasmic Reticulum Membrane, Single-Pass Type I Membrane, Autophagosome Membrane, Axon | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O75787 | ||
| Product name | Anti-ATP6AP2 / Renin receptor Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45898 | ||
| Supplier’s Catalog No | IGX-45898 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse | ||
| Applications | ELISA, WB | ||
| Recommended dilutions | WB: 1:1000-1:5000 | ||
| Molecular weight | Predicted band size: 40, 36 KDa. Observed band size: 40 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Renin receptor protein (17-350AA) | ||
| Specificity | ATP6AP2 antibody detects endogenous level of ATP6AP2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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