Anti-HK1 Antibody
Catalog No : IGX-45949
262.00€
188.00€
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| Description | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PMID:1637300, PMID:25316723, PMID:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PMID:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate . Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PMID:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PMID:27374331). | ||
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| Other names | Hexokinase-1, EC 2.7.1.1, Brain form hexokinase, Hexokinase type I, HK I, HK1 | ||
| Cellular localization | Cytosol, Mitochondrion, Mitochondrion Outer Membrane, Peripheral Membrane | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P19367 | ||
| Product name | Anti-HK1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-45949 | ||
| Supplier’s Catalog No | IGX-45949 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Rat | ||
| Applications | ELISA, WB | ||
| Recommended dilutions | WB: 1:1000-1:5000 | ||
| Molecular weight | Predicted band size: 103 KDa. Observed band size: 103 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Hexokinase-1 protein (13-475AA) | ||
| Specificity | HK1 antibody detects endogenous level of HK1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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