Anti-TNF Antibody
Catalog No : IGX-46009
262.00€
188.00€
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| Description | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation . Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance . The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. | ||
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| Other names | Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, [Cleaved into: Tumor necrosis factor, membrane form, N-terminal fragment, NTF, Intracellular domain 1, ICD1, Intracellular domain 2, ICD2, C-domain 1, C-domain 2, Tumor necrosis factor, soluble form], TNF, TNFA TNFSF2 | ||
| Cellular localization | Plasma Membrane, Membrane, Single-Pass Type Ii Membrane, Membrane, Secreted | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P23383 | ||
| Product name | Anti-TNF Antibody | ||
|---|---|---|---|
| Catalog No | IGX-46009 | ||
| Supplier’s Catalog No | IGX-46009 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Sheep | ||
| Applications | ELISA, WB | ||
| Recommended dilutions | WB: 1:1000-1:5000 | ||
| Molecular weight | Predicted band size: 26 KDa. Observed band size: 26 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Sheep Tumor necrosis factor protein (78-234AA) | ||
| Specificity | TNF antibody detects endogenous level of TNF protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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