Anti-ZC3HC1 Antibody
Catalog No : IGX-46211
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. | ||
|---|---|---|---|
| Other names | Nuclear-interacting partner of ALK, Nuclear-interacting partner of anaplastic lymphoma kinase, hNIPA, Zinc finger C3HC-type protein 1, ZC3HC1, NIPA | ||
| Cellular localization | Nucleus | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q86WB0 | ||
| Product name | Anti-ZC3HC1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-46211 | ||
| Supplier’s Catalog No | IGX-46211 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB | ||
| Recommended dilutions | WB: 1:1000-1:5000 | ||
| Molecular weight | Predicted band size: 56 KDa. Observed band size: 54 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Nuclear-interacting partner of ALK protein (1-260AA) | ||
| Specificity | ZC3HC1 antibody detects endogenous level of ZC3HC1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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