Anti-CYP11B1 / Cytochrome P450 11B1 mitochondrial Antibody
Catalog No : IGX-46263
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| Description | A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PMID:18215163). Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively (PMID:18215163). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PMID:18215163). | ||
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| Other names | Cytochrome P450 11B1, mitochondrial, CYPXIB1, Cytochrome P-450c11, Cytochrome P450C11, Steroid 11-beta-hydroxylase, EC 1.14.15.4, CYP11B1, S11BH | ||
| Cellular localization | Mitochondrion, Mitochondrion Inner Membrane, Peripheral Membrane | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P15538 | ||
| Product name | Anti-CYP11B1 / Cytochrome P450 11B1 mitochondrial Antibody | ||
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| Catalog No | IGX-46263 | ||
| Supplier’s Catalog No | IGX-46263 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse | ||
| Applications | ELISA, WB | ||
| Recommended dilutions | WB: 1:1000-1:5000 | ||
| Molecular weight | Predicted band size: 58 KDa. Observed band size: 58 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 11B1, mitochondrial protein (88-323AA) | ||
| Specificity | CYP11B1 antibody detects endogenous level of CYP11B1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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