Anti-CASTOR2 / Cytosolic arginine sensor for mTORC1 subunit 2 Antibody
Catalog No : IGX-46306
262.00€
188.00€
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| Description | Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. | ||
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| Other names | Cytosolic arginine sensor for mTORC1 subunit 2, Cellular arginine sensor for mTORC1 protein 2, GATS-like protein 2, CASTOR2, GATSL1 GATSL2 | ||
| Cellular localization | Cytosol | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | A6NHX0 | ||
| Product name | Anti-CASTOR2 / Cytosolic arginine sensor for mTORC1 subunit 2 Antibody | ||
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| Catalog No | IGX-46306 | ||
| Supplier’s Catalog No | IGX-46306 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB | ||
| Recommended dilutions | WB: 1:1000-1:5000 | ||
| Molecular weight | Predicted band size: 37 KDa. Observed band size: 37 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA) | ||
| Specificity | CASTOR2 antibody detects endogenous level of CASTOR2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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