| Description |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PMID:10066435, PMID:10497169, PMID:10644755, PMID:10835356, PMID:11238952, PMID:11359933, PMID:11994270, PMID:12791267, PMID:12902344, PMID:14603323, PMID:14681206, PMID:14988407, PMID:15448698, PMID:15917222, PMID:16371461, PMID:25503564, PMID:25704143, PMID:9859996, PMID:22087322). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PMID:12077367, PMID:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PMID:10835356, PMID:11238952, PMID:14681206, PMID:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PMID:10066435, PMID:10497169, PMID:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PMID:10066435). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PMID:25704143, PMID:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 . Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PMID:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PMID:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PMID:21258371, PMID:18354482). |
