Anti-CREB3 Antibody
Catalog No : IGX-48213
237.00€
175.00€
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| Description | Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PMID:9271389, PMID:19779205, PMID:10984507, PMID:15845366, PMID:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PMID:15845366, PMID:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PMID:19779205, PMID:15001559, PMID:17296613). Associates with chromatin to the HERPUD1 promoter (PMID:16940180). Also induces transcriptional activation of chemokine receptors (PMID:18587271, PMID:17296613). Processed cyclic AMP-responsive element-binding protein 3: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3'). Isoform 2: Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells. (Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression. Isoform 1: (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 1: (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein. Processed cyclic AMP-responsive element-binding protein 3: (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral promoters. Processed cyclic AMP-responsive element-binding protein 3: (Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein. | ||
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| Other names | Cyclic AMP-responsive element-binding protein 3, CREB-3, cAMP-responsive element-binding protein 3, Leucine zipper protein, Luman, Transcription factor LZIP-alpha, [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3, N-terminal Luman, Transcriptionally active form,], CREB3, LZIP | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Single-Pass Type Ii Membrane, Golgi Apparatus, Nucleus, Cytoplasm | ||
| Research area | Microbiology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O43889 | ||
| Product name | Anti-CREB3 Antibody | ||
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| Catalog No | IGX-48213 | ||
| Supplier’s Catalog No | IGX-48213 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC | ||
| Recommended dilutions | WB: 1:500-1:1000, IHC: 1:20-200 | ||
| Molecular weight | Predicted band size: 44 KDa. Observed band size: 44 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cyclic AMP-responsive element-binding protein 3 protein (1-230AA) | ||
| Specificity | CREB3 antibody detects endogenous level of CREB3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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