Anti-LRPPRC Antibody
Catalog No : IGX-51038
262.00€
188.00€
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| Description | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA . | ||
|---|---|---|---|
| Other names | Leucine-rich PPR motif-containing protein, mitochondrial, 130 kDa leucine-rich protein, LRP 130, GP130, LRPPRC, LRP130 | ||
| Cellular localization | Nucleoplasm, Nucleus Inner Membrane, Nucleus Outer Membrane, Mitochondrion | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P42704 | ||
| Product name | Anti-LRPPRC Antibody | ||
|---|---|---|---|
| Catalog No | IGX-51038 | ||
| Supplier’s Catalog No | IGX-51038 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC, IF, IP | ||
| Recommended dilutions | WB: 1:500-1:5000, IHC: 1:200-1:500, IF: 1:50-1:200, IP: 1:200-1:2000 | ||
| Molecular weight | Predicted band size: 158 KDa. Observed band size: 158 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Leucine-rich PPR motif-containing protein, mitochondrial protein (901-1036AA) | ||
| Specificity | LRPPRC antibody detects endogenous level of LRPPRC protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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