Anti-CDH1 Antibody Monoclonal
Catalog No : IGX-59118
282.00€
201.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Cadherins are calcium-dependent cell adhesion proteins (PMID:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PMID:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. | ||
|---|---|---|---|
| Other names | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3], CDH1, CDHE UVO | ||
| Cellular localization | Endosome, Trans-Golgi Network, Plasma Membrane, Membrane, Single-Pass Type I Membrane, Adherens Junction | ||
| Research area | Cancer, Developmental biology, Signal transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P12830 | ||
| Product name | Anti-CDH1 Antibody Monoclonal | ||
|---|---|---|---|
| Catalog No | IGX-59118 | ||
| Supplier’s Catalog No | IGX-59118 | ||
| Supplier | ImuGeX | ||
| Host species | Mouse | ||
| Species reactivity | Human, Mouse | ||
| Applications | ELISA, WB, IF, Flow cyto | ||
| Recommended dilutions | WB: 1:500-1:5000, IF: 1:50-1:200 | ||
| Molecular weight | Predicted band size: 98 KDa Observed band size: 110, 120 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cadherin-1 protein (155-707AA) | ||
| Specificity | This antibody detects total endogenous levels of CDH1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Monoclonal | ||
| Isotype | IgG1 | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Preservative: 0.03% Proclin, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved