Anti-MUC18 / CD146 Antibody
Catalog No : IGX-59258
282.00€
201.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. | ||
|---|---|---|---|
| Other names | Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18 | ||
| Cellular localization | Membrane | ||
| Research area | Immunology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P43121 | ||
| Product name | Anti-MUC18 / CD146 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-59258 | ||
| Supplier’s Catalog No | IGX-59258 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC, IF, Flow cyto | ||
| Recommended dilutions | WB: 1:500-1:5000, IHC: 1:50-1:500, IF: 1:30-1:200 | ||
| Molecular weight | Predicted band size: 72 KDa Observed band size: 110 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | A synthesized peptide | ||
| Specificity | This antibody detects total endogenous levels of CD146 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Monoclonal | ||
| Isotype | Rabbit IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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