Anti-BCL2 Antibody
Catalog No : IGX-59301
282.00€
201.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PMID:17418785). | ||
|---|---|---|---|
| Other names | Apoptosis regulator Bcl-2, BCL2 | ||
| Cellular localization | Mitochondrion Outer Membrane, Single-Pass Membrane, Endoplasmic Reticulum Membrane, Nucleus Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P10415 | ||
| Product name | Anti-BCL2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-59301 | ||
| Supplier’s Catalog No | IGX-59301 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse, Rat | ||
| Applications | ELISA, WB, IHC, Flow cyto; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500 | ||
| Recommended dilutions | WB: 1:500-1:5000, IHC: 1:50-1:500 | ||
| Molecular weight | |||
| Conjugate | Unconjugated | ||
| Immunogen | A synthesized peptide | ||
| Specificity | This antibody detects total endogenous levels of BCL2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Monoclonal | ||
| Isotype | Rabbit IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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