Anti-ARNT / HIF-1beta Antibody
Catalog No : IGX-59428
282.00€
201.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PMID:28396409). | ||
|---|---|---|---|
| Other names | HIF1 beta, HIF-1-beta, HIF1 beta, HIF-1-beta, Aryl hydrocarbon receptor nuclear translocator, HIF-1β, HIF1β, HIF 1-beta, HIF-1beta, HIF1B, HIF-1b, HIF1-b, Class E basic helix-loop-helix protein 2, bHLHe2 Dioxin receptor, nuclear translocator Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta | ||
| Cellular localization | Nucleus | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P27540 | ||
| Product name | Anti-ARNT / HIF-1beta Antibody | ||
|---|---|---|---|
| Catalog No | IGX-59428 | ||
| Supplier’s Catalog No | IGX-59428 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC, IP | ||
| Recommended dilutions | WB: 1:500-1:5000, IHC: 1:50-1:200, IP: 1:200-1:1000 | ||
| Molecular weight | Predicted band size: 87 KDa Observed band size: 87 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | A synthesized peptide derived from human ARNT | ||
| Specificity | This antibody detects total endogenous levels of ARNT/HIF-1beta protein. | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Monoclonal | ||
| Isotype | Rabbit IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved