Anti-FOS (p55) / Proto-oncogene c-Fos Antibody
Catalog No : IGX-59460
282.00€
201.00€
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| Description | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. | ||
|---|---|---|---|
| Other names | Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, FOS, G0S7 | ||
| Cellular localization | Cytoplasm, Endoplasmic reticulum, Nucleus | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P01100 | ||
| Product name | Anti-FOS (p55) / Proto-oncogene c-Fos Antibody | ||
|---|---|---|---|
| Catalog No | IGX-59460 | ||
| Supplier’s Catalog No | IGX-59460 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse | ||
| Applications | ELISA, WB, IHC, IF, Flow cyto; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200 | ||
| Recommended dilutions | WB: 1:500-1:5000, IHC: 1:50-1:200, IF: 1:20-1:200 | ||
| Molecular weight | Predicted band size: 41 KDa Observed band size: 62 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | A synthesized peptide derived from human FOS | ||
| Specificity | This antibody detects total endogenous levels of FOS protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Monoclonal | ||
| Isotype | Rabbit IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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