Anti-Immunoglobulin IgG, IgA ,IgM H+L, Preadsorbed, Mouse -TXRD Antibody
Catalog No : ABM-Y106595
498.43€
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| Description | IgG is a monomeric immunoglobulin, built of two heavy chains and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B-cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. | ||
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| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | |||
| Product name | Anti-Immunoglobulin IgG, IgA ,IgM H+L, Preadsorbed, Mouse -TXRD Antibody | ||
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| Catalog No | ABM-Y106595 | ||
| Supplier’s Catalog No | Y106595 | ||
| Supplier | Applied Biological Materials | ||
| Host species | Others | ||
| Species reactivity | Mouse | ||
| Applications | Optimal dilution should be determined by the researcher. | ||
| Recommended dilutions | Optimal dilution should be determined by the researcher. | ||
| Molecular weight | |||
| Conjugate | Texa Red-conjugated | ||
| Immunogen | N/A | ||
| Specificity | |||
| Storage | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid repeated freeze and thaw cycles. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | |||
| Concentration | It may differ from batch to batch. Please contact us to confirm it. | ||
| Storage buffer | N/A | ||
| Formulation | Liquid | ||
| Purification | Affinity purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | One year when stored properly according to instructions. | ||
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