Anti-ALK,CD246 antibody

Catalog No : FT-FNab00309
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Description Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
Other names
Cellular localization
Research area Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience
Note This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID Q9UM73
Product name Anti-ALK,CD246 antibody
Catalog No FT-FNab00309
Supplier’s Catalog No FNab00309
Supplier Fine Test (Wuhan Fine Biotech)
Host species Rabbit
Species reactivity Human, Mouse, Rat
Applications ELISA, IHC, WB
Recommended dilutions WB: 1:500-1:2000, IHC: 1:20-1:200
Molecular weight 140-220 kDa
Conjugate Unconjugated
Immunogen anaplastic lymphoma receptor tyrosine kinase
Specificity N/A
Storage Store at -20°C. Avoid repeated freeze and thaw cycles.
Clonality Polyclonal
Isotype IgG
Clone ID N/A
Concentration 1 mg/mL
Storage buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Formulation Liquid
Purification Immunogen affinity purified, ≥95% as determined by SDS-PAGE
Handling This product contains NaN3 as preservative, please take appropriate care when handling this product.
Reactivity life 12 months when stored properly according to instructions.