Anti-ALK,CD246 antibody
Catalog No : FT-FNab00309
294.00€
0.00€
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| Description | Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity. | ||
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| Other names | |||
| Cellular localization | |||
| Research area | Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UM73 | ||
| Product name | Anti-ALK,CD246 antibody | ||
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| Catalog No | FT-FNab00309 | ||
| Supplier’s Catalog No | FNab00309 | ||
| Supplier | Fine Test (Wuhan Fine Biotech) | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse, Rat | ||
| Applications | ELISA, IHC, WB | ||
| Recommended dilutions | WB: 1:500-1:2000, IHC: 1:20-1:200 | ||
| Molecular weight | 140-220 kDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | anaplastic lymphoma receptor tyrosine kinase | ||
| Specificity | N/A | ||
| Storage | Store at -20°C. Avoid repeated freeze and thaw cycles. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 | ||
| Formulation | Liquid | ||
| Purification | Immunogen affinity purified, ≥95% as determined by SDS-PAGE | ||
| Handling | This product contains NaN3 as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions. | ||
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