Imugex

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Categories: Antibodies / Primary Antibodies

Description			Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Other names
Cellular localization
Research area			Immunology, Cardiovascular
Note			This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID			P12814

Storage			Store at -20°C. Avoid repeated freeze and thaw cycles.
Clonality			Polyclonal
Isotype			IgG
Clone ID			N/A
Concentration			1 mg/mL
Storage buffer			PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Formulation			Liquid
Purification			Immunogen affinity purified, ≥95% as determined by SDS-PAGE
Handling			This product contains NaN3 as preservative, please take appropriate care when handling this product.
Reactivity life			12 months when stored properly according to instructions.