Anti-MAP3K3 antibody
Catalog No : FT-FNab09784
302.00€
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| Description | The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics. | ||
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| Other names | |||
| Cellular localization | |||
| Research area | Signal Transduction, Immunology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q99759 | ||
| Product name | Anti-MAP3K3 antibody | ||
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| Catalog No | FT-FNab09784 | ||
| Supplier’s Catalog No | FNab09784 | ||
| Supplier | Fine Test (Wuhan Fine Biotech) | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC | ||
| Recommended dilutions | WB: 1:200-1:2000, IHC: 1:50-1:500 | ||
| Molecular weight | 74 kDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | mitogen-activated protein kinase kinase kinase 3 | ||
| Specificity | N/A | ||
| Storage | Store at -20°C. Avoid repeated freeze and thaw cycles. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 | ||
| Formulation | Liquid | ||
| Purification | Immunogen affinity purified, ≥95% as determined by SDS-PAGE | ||
| Handling | This product contains NaN3 as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions. | ||
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