Imugex

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Categories: Antibodies / Primary Antibodies

Description			The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Other names
Cellular localization
Research area			Neuroscience, Cancer, Developmental biology
Note			This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID			Q07812

Storage			Store at -20°C. Avoid repeated freeze and thaw cycles.
Clonality			Polyclonal
Isotype			IgG
Clone ID			N/A
Concentration			1 mg/mL
Storage buffer			PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Formulation			Liquid
Purification			Immunogen affinity purified, ≥95% as determined by SDS-PAGE
Handling			This product contains NaN3 as preservative, please take appropriate care when handling this product.
Reactivity life			12 months when stored properly according to instructions.