Imugex

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Categories: Antibodies / Primary Antibodies

Description			Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Other names
Cellular localization
Research area			Cancer, Immunology, Metabolism
Note			This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID			Q14457

Storage			Store at -20°C. Avoid repeated freeze and thaw cycles.
Clonality			Polyclonal
Isotype			IgG
Clone ID			N/A
Concentration			1 mg/mL
Storage buffer			PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Formulation			Liquid
Purification			Immunogen affinity purified, ≥95% as determined by SDS-PAGE
Handling			This product contains NaN3 as preservative, please take appropriate care when handling this product.
Reactivity life			12 months when stored properly according to instructions.