Anti-CCL2 / MCP1 Antibody
Catalog No : IGX-2103
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| Description | Acts as a ligand for C-C chemokine receptor CCR2 . Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions . Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils . Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PMID:29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PMID:29993042). | ||
|---|---|---|---|
| Other names | C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, SCYA2 | ||
| Cellular localization | Secreted | ||
| Research area | Immunology, Signal Transduction, Cancer, Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P13500 | ||
| Product name | Anti-CCL2 / MCP1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-2103 | ||
| Supplier’s Catalog No | IGX-2103 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse, Rat | ||
| Applications | WB, IHC, ICC, IF, ELISA | ||
| Recommended dilutions | WB:1:1000-1:3000, IHC:1:20-1:200, ICC/IF:1:100-1:500, ELISA: 1:20000-1:40000 | ||
| Molecular weight | Predicted band size: 11 KDa. Observed band size: 14 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human C-C motif chemokine 2 protein (24-99AA) | ||
| Specificity | MCP1 Antibody detects endogenous levels of total MCP1 protein. | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol | ||
| Formulation | Liquid | ||
| Purification | Immunogen Affinity Purified | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions. | ||
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