Anti-CaV2.3 Antibody
Catalog No : IGX-2111
277.00€
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| Description | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PMID:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. | ||
|---|---|---|---|
| Other names | CACNA1E, Brain calcium channel II, BII, Calcium channel L type alpha-1 polypeptide isoform 6, CACH6, CACNL1A6, Voltage-gated calcium channel subunit alpha Cav2.3, CAC1E | ||
| Cellular localization | Membrane | ||
| Research area | Cardiovascular, Neuroscience, Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q15878 | ||
| Product name | Anti-CaV2.3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-2111 | ||
| Supplier’s Catalog No | IGX-2111 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse, Rat. Predicted reactivity: Canine, Horse (reactivity is predicted based on sequence homology). | ||
| Applications | WB, ICC, IF, ELISA | ||
| Recommended dilutions | WB: 1:1000-3000, ICC/IF: 1:100-1:500, ELISA: 1:20000-1:40000 | ||
| Molecular weight | Predicted band size: 262 KDa. Observed band size: 262 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | A synthetic peptide derived from human CACNA1E (CaV2.3) corresponding to amino acids in the internal region. | ||
| Specificity | CaV2.3 Antibody detects endogenous levels of total CaV2.3 protein. | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol | ||
| Formulation | Liquid | ||
| Purification | Immunogen Affinity Purified | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions. | ||
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