Anti-CaV1.2 Antibody
Catalog No : IGX-2123
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| Description | This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. | ||
|---|---|---|---|
| Other names | CACNA1C, CAC1C, CACH2, CACN2, CACNL1A1, CCHL1A1, Calcium channel L type alpha-1 polypeptide isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.3 | ||
| Cellular localization | Plasma Membrane, Sarcolemma, T-tubule, Perikaryon, Dendrite | ||
| Research area | Cardiovascular, Neuroscience, Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q13936 | ||
| Product name | Anti-CaV1.2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-2123 | ||
| Supplier’s Catalog No | IGX-2123 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse, Rat. Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Canine (reactivity is predicted based on sequence homology). | ||
| Applications | WB, ELISA | ||
| Recommended dilutions | WB: 1:500-1:2000, ELISA: 1:20000-1:40000 | ||
| Molecular weight | Predicted band size: 249 KDa. Observed band size: 249 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | A synthetic peptide derived from human CACNA1C corresponding to C-terminal amino acids. | ||
| Specificity | CaV1.2 antibody detects endogenous levels of total CaV1.2 protein. | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol | ||
| Formulation | Liquid | ||
| Purification | Immunogen Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions. | ||
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