Anti-SARS-CoV-2 Spike Protein antibody Monoclonal

Catalog No : IGX-29577
275.00€
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Description Spike glycoprotein: May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activitySpike protein. S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Can be alternatively processed by host furin (PubMed:32362314). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Other names Human Novel Coronavirus S antibody, Spike protein, S peotein, protein S, SARS-CoV-2, 2019-nCoV, COVID19, COVID-19, Coronavirus S protein antibody, SARS-CoV-2 S protein antibody, 2019-nCoV Spike protein antibody
Cellular localization Host cell membrane
Research area Immunology, Cardiovascular, Neuroscience, Cell Biology
Note This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID P0DTC2
Product name Anti-SARS-CoV-2 Spike Protein antibody Monoclonal
Catalog No IGX-29577
Supplier’s Catalog No IGX-29577
Supplier ImuGeX
Host species Rabbit
Species reactivity Human Novel Coronavirus
Applications ELISA
Recommended dilutions ELISA: 1:1000-1:5000
Molecular weight 141 KDa
Conjugate Unconjugated
Immunogen Recombinant Human Novel Coronavirus Spike glycoprotein (AA: 16-685)
Specificity This antibody binds to SARS-CoV-2 spike protein.
Storage Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity.
Clonality Polyclonal
Isotype IgG
Clone ID N/A
Concentration Concentration can vary between different batches.
Storage buffer Phosphate-Buffered Saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol.
Formulation Liquid
Purification >95%, Protein G purified
Handling This product contains Proclin as preservative, please take appropriate care when handling this product.
Reactivity life 12 months when stored properly according to instructions (provided antibody remains sterile).