Ganglioside GM1, Bovine (Monosialoganglioside GM1)
Catalog No : USB-297010
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| Product name | Ganglioside GM1, Bovine (Monosialoganglioside GM1) | ||
|---|---|---|---|
| Catalog No | USB-297010 | ||
| Supplier’s Catalog No | 297010 | ||
| Supplier | US Biologicals | ||
| Source antigen | Bovine brain | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 1546.82 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | |||
| Purity | ≥95% | ||
| Form | Whit to off-white powder | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Description | Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gan- gliosides has been linked to several diseases. Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-kB and activation of dendritic cells. GM1 has also been shown to improve Parkinson's disease symptoms and slow it's progression. Source: Bovine brain Synonyms: Monosialoanglioside GM1, sodium salt (Bovine brain CAS No: 37758-47-7 Molecular Formula: C73H131N3O31 Molecular Weight: 1546.82 Appearance: Whit to off-white powder Purity: ≥95% Solubility: Soluble in chloroform/methanol mix (2:1). Slighlty soluble in water (micellar aggregates). Applications: Suitable for use as an antigen and receptor for cholera toxin, growth inhibitor marker in fibroblasts and marker for lymphoid subpopulations. Stable for the majority of sialidase. Sequence: II3Neu5AcGgOse4Cer;b-Gal-(1-3)-b-GalNAc-(1-4)-[a-Neu5Ac-(2-3)-]b-Gal-(1-4)-b-Glc-(1-1)-Cer Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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