Imugex

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Categories: Biochemicals / Biochemicals

Storage			4°C Do Not Freeze
Other names
Grade			Highly Purified
Purity			≥95% (SDS-PAGE)
Form			Supplied as a liquid in 0.1M HEPES, 0.1M sodium chloride, pH 7.4, 0.02% sodium azide
Reactivity life			12 months
Note			For reserch purpose only
Description			Plasmin is a serine protease with broad specificity which, in addition to cleavage of fibrin, is capable of activation and/or degradation of compounds of the coagulation, kinin generation and complement systems. Although plasmin can be inhibited by a number of plasma protease inhibitors in vitro, regulation of plasmin in vivo is thought to occur mainly through its interaction with a2-antiplasmin, and to a lesser extent, a2-macroglobulin. Human Lys-plasmin is immobilized on agarose resin by coupling of primary amines. Plasmin retains catalytic activity when coupled and may be used to efficiently activate single-chain tissue-type plasminogen activator tPA and uPA to the two-chain form(1). It may also be used to convert plasminogen from its native Glu form to the Lys form by removing the first 77 amino acids. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.