Hepatitis C Virus NS3, c33c, aa1192-1459, Genotype 2b, Recombinant (HCV)
Catalog No : USB-H1920-23B4
1249.46€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | Hepatitis C Virus NS3, c33c, aa1192-1459, Genotype 2b, Recombinant (HCV) | ||
|---|---|---|---|
| Catalog No | USB-H1920-23B4 | ||
| Supplier’s Catalog No | H1920-23B4 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (10% PAGE Coomassie staining). | ||
| Form | Supplied as a liquid in 25mM tris-HCl, 1mM EDTA, 1.5M urea, 50% glycerol. No preservative added. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (10% PAGE Coomassie staining). | ||
| Description | Hepatitis C Virus (HCV) NS3 c33c (aa1192-1459), Subtype 2b, Recombinant. Contains full-length HCV NS3 (c33c) immunodominant region. Not full-length NS3. Contains GST fusion partner. Immunoreactive with HCV positive sera including sera with antibodies to NS3 secondary structure domains. The nonstructural protein NS3 of the hepatitis C virus (HCV) is indispensable for virus replication and a multifunctional enzyme that contains three catalytic activities such as serine protease, helicase, and NTPase. The N-terminal domain of the protein contains protease activity and the C-terminal domain contains nucleotide triphosphatase and RNA helicase activity. It has been shown that NS2/3 cleavage is mediated by NS2-3 protease, whereas NS3 serine protease is responsible for the other four cleavage sites of the nonstructural (NS) region. Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa1250/1251), A (within aa1250-1334), A/B (around aa1323 and 1334), and B/C (around aa1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis. Source: E. coli Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
Product Details
© 2020 Imugex All Rights Reserved