HIV-1 gp41, Recombinant, His-Tag (Human Immunodeficiency Virus Type 1)
Catalog No : USB-208996
531.05€
0.00€
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| Product name | HIV-1 gp41, Recombinant, His-Tag (Human Immunodeficiency Virus Type 1) | ||
|---|---|---|---|
| Catalog No | USB-208996 | ||
| Supplier’s Catalog No | 208996 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 69 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (HPLC, SDS-PAGE) | ||
| Form | Supplied as a liquid in 20mM sodium carbonate, pH 9.6, 0.02% sodium azide. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (HPLC, SDS-PAGE) | ||
| Description | Human immunodeficiency virus (HIV) is a retrovirus that can lead to a condition in which the immune system begins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosis in infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell- mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lent viruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genome is converted to double-stranded DNA by a virally encoded reverse transcriptase that is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integrase so that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latent and the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells. Source: Recombinant protein corresponding to a non-glycosylated polypeptide chain, containing the envelope glycoprotein 41 (subtype-B) gene of the HIV1, fused to 6X His-tag /chaperone protein at N-terminus, expressed in E. coli. Molecular Weight: ~69kD Specificity: Immunoreactive with all sera of HIV-1 infected individuals. Applications: Suitable for use as an antigen in ELISA and Western Blot, excellent for early detection of HIV sero convertors with minimal specificity problems. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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