Filamentous Hemagglutinin (FHA)
Catalog No : USB-215941
502.31€
0.00€
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| Product name | Filamentous Hemagglutinin (FHA) | ||
|---|---|---|---|
| Catalog No | USB-215941 | ||
| Supplier’s Catalog No | 215941 | ||
| Supplier | US Biologicals | ||
| Source antigen | B. pertussis | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 200 | ||
| Storage | 4°C Do Not Freeze | ||
|---|---|---|---|
| Other names | |||
| Grade | |||
| Purity | Band representing 84% of the protein when examined on 4-12% SDS-polyacrylamide gels | ||
| Form | Supplied as a lyophilized powder from 0.05M Tris, 0.5M sodium chloride, pH 8.0, 1.25% trehalose. Reconstitute with 500ul sterile ddH2O. Do not vortex. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Band representing 84% of the protein when examined on 4-12% SDS-polyacrylamide gels | ||
| Description | The initial step in establishing a Bordetella pertussis infection is attachment of the bacteria to the epithelial lining of the host respiratory tract. Two B. pertussis virulence factors are key in this process, filamentous hemagglutinin (FHA) and fimbriae (Fim). FHA , which is both surface- associated and secreted by B. pertussis, is a multifunctional protein which promotes the attachment of the bacteria through several binding domains. Because FHA is highly immunogenic, it is included in many of the acellular vaccines. Additionally, FHA acts through multiple pathways to modulate the host immune response; an example of this type of activity is suppression of the development of the host IL-17-mediated inflammatory response. FHA is a large, 220kD beta-helical protein which is isolated from the native Bordetella pertussis strain 165. Source: Filamentous Hemagglutinin, strain 165 from B. pertussis. Molecular Weight: ~220kD Biological Activity: Using glutaraldehyde fixed rabbit red blood cells, this lot exhibited strong hemagglutination activity when examined in a modification of the method of Sato, et al. Storage and Stability: Lyophilized powder may be stored at 4°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at 4°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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