Hemagglutinin Influenza Virus (H1N1), Recombinant, His-Tag, aa1-529 (A/Puerto Rico/8/1934)
Catalog No : USB-506268
558.64€
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| Product name | Hemagglutinin Influenza Virus (H1N1), Recombinant, His-Tag, aa1-529 (A/Puerto Rico/8/1934) | ||
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| Catalog No | USB-506268 | ||
| Supplier’s Catalog No | 506268 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, HEK293 cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 59 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (Highly Purified) | ||
| Form | Supplied as a liquid in DPBS, pH 7.4. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (Highly Purified) | ||
| Description | Influenza, commonly known as “the flu”, is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenza virus A, Influenza virus B, and Influenza virus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. Influenza virus hemagglutinin (HA) is a trimer of identical subunits, each of which contains two polypeptides that result from proteolytic cleavage of a single precursor. The two polypeptides are designated HA1 and HA2. The HA2 monomer is a long helical chain, anchored into the membrane, and is “topped” by a “globule” of HA1. Cleavage of the precursor is essential for activation of membrane fusion potential and hence infectivity. For HAs of most subtypes, the site of cleavage is a single arginine residue, and cleavage occurs extracellularly by an as yet unidentified enzyme. The Puerto Rico strain isolated in 1934 is one of the most commonly used laboratory strains, and formed the basis of early influenza vaccines. The structure of HA has been reviewed by Gamblin and Skehel in 2010. Source: Recombinant protein corresponding to the HA sequence of the A/Puerto Rico/8/1934 (H1N1) strain (Accession #NP_040980), expressing Asp18-Gn529, and is fused with a 8x Gly-Ser linker and a 6x polyhistidine tag at the C-terminus, expressed in HEK293 cells. Strain: A/Puerto Rico/8/1934 (H1N1) Molecular Weight: ~59kD (calculated), DTT-reduced migrates as a band of ~70-80kD. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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