Neuraminidase Influenza A (H5N1), Recombinant, aa36-449, His-Tag ([A/Thailand/1(KAN-1)/2004 (H5N1)])
Catalog No : USB-506328
1025.32€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | Neuraminidase Influenza A (H5N1), Recombinant, aa36-449, His-Tag ([A/Thailand/1(KAN-1)/2004 (H5N1)]) | ||
|---|---|---|---|
| Catalog No | USB-506328 | ||
| Supplier’s Catalog No | 506328 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, HEK293 cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 46.1 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in DPBS, pH 7.4. Reconstitute with 500ul sterile ddH2O. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | Influenza, commonly known as “the flu”, is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenza virus A, Influenza virus B, and Influenza virus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. Influenza virus neuraminidase (NA) is a mushroom-shaped tetramer of identical subunits. Each of the subunits that form the head of the mushroom is made up of a propeller-like structure, the blades of which are formed by four antiparallel strands of beta-structure. The enzyme active site is located at roughly the center of each subunit. During virus replication, Influenza virus neuraminidase removes sialic acid from cellular glycoproteins and glycolipids and from both of the virus glycoproteins. As a result, newly assembled viruses are prevented from binding to the infected cell surface and from aggregating with each other through HA-sialic acid interactions. Instead, they are released from the cell to infect new cells and spread the infection.The structure of NA has been reviewed by Gamblin and Skehel in 2010. Source: Recombinant protein corresponding to Influenza virus neuraminidase protein from the NA sequence of the A/Thailand/1(KAN-1)/2004 (H5N1) strain, expressing His36- Lys449, and is fused with a 6xHis-Tag at the C-terminus, expressed in HEK293 cells. Strain: A/Thailand/1(KAN-1)/2004 (H5N1) Molecular Weight: ~46.1kD (calculated) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
Product Details
© 2020 Imugex All Rights Reserved