Herpes Simplex Virus gG2, Strain G
Catalog No : USB-518160
747.15€
0.00€
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| Product name | Herpes Simplex Virus gG2, Strain G | ||
|---|---|---|---|
| Catalog No | USB-518160 | ||
| Supplier’s Catalog No | 518160 | ||
| Supplier | US Biologicals | ||
| Source antigen | HSV2 infected BHK cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | ≥80% | ||
| Form | Supplied as a liquid in 50mM Tris-HCl, pH 7.6, 150mM sodium chloride, 0.5% IGEPAL CA-630. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥80% | ||
| Description | HSV-2 is often known as genital herpes, and is one of the most common sexually transmitted diseases. Infection with HSV-2 can cause genital ulcerations, which may be accompanied by fever, local lymphadenopathy and dysuria, and infected individuals have a lifelong risk of transmitting the viral infection to their sexual partners. There is evidence of an increased risk of human immunodeficiency virus (HIV) acquisition with herpes-associated genital ulceration (1) and pregnant women infected with HSV-2 can infect children during delivery (2,3), causing neonatal herpes. Without therapy, mortality for untreated infants who develop disseminated infection exceeds 70%, with many survivors developing neurological impairment related to HSV encephalitis. Around 70% of mothers who transmit HSV to their children are asymptomatic at delivery. Importantly, it has been shown that transmission rates are much higher during a primary infection of the mother (>50%) compared to recurrent infection (<5%) (4). This is important in relation to immunoassays for maternal HSV-2 specific IgG and IgM, where primary infections are characterized by IgM responses but no IgG response. After primary HSV infection, the virus colonizes sensory neurons, and the infection may reactivate causing recurrent sub-clinical or clinical infection. Many serologic methods for assessing HSV sero-status use viral lysate as antigens. However, the viral lysate assays are unable to differentiate HSV-1 infections from HSV-2 infections due to the antigenic similarity between the viruses. Given that HSV-1 infection is extremely common in adults, such assays are unable to detect HSV-2 infection with any confidence. The purified Herpes Simplex virus gG2 protein can be used to develop specific HSV-2 assays, which are valuable in determining the HSV-2 status of expectant mothers, and allowing clinicians to make appropriate therapeutic interventions for potentially infected newborns. Tests have shown excellent performance in assays for the distinguishing between HSV1 and HSV2-infected patients. Herpes Simplex virus gG2 protein is specific to the HSV-2 virus, and shares very little sequence similarity to HSV-1. The protein can therefore be used as an antigen in immunoassays to differentiate between the two viruses. Description: Native HSV2 gG2 protein, Strain G, purified from HSV2 infected BHK cells Reactivity: Detection of HSV2 positive sera by ELISA (within 20% of Gold Standard). No detection of HSV1 positive sera by ELISA (within 20% of Gold Standard). Inactivation: 0.5% IGEPAL CA-630 Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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