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Categories: Peptides & Proteins / Proteins

Product name			Calreticulin, Recombinant, aa18-417, His-Tag (CRP55, Calregulin, Endoplasmic Reticulum Resident Protein 60, ERp60, HACBP, grp60, CRTC, CALR)
Catalog No			USB-149797
Supplier’s Catalog No			149797
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			46

Storage			-70°C
Other names
Grade			Purified
Purity			~90%
Form			Supplied as a liquid in 10mM Tris, pH 8.0, 0.002% sodium azide, 3mM sodium chloride.
Reactivity life			6 months
Note			For reserch purpose only
Purity			~90%
Description			Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an aa sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. Source: Recombinant protein corresponding to CALR, fused to His-tag at N-terminal expressed in E.coli. Molecular Weight: ~46kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.