KRT17, Recombinant, Bovine, aa1-441, His-SUMO-Tag (Keratin, Type I Cytoskeletal 17)
Catalog No : USB-373954
506.91€
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| Product name | KRT17, Recombinant, Bovine, aa1-441, His-SUMO-Tag (Keratin, Type I Cytoskeletal 17) | ||
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| Catalog No | USB-373954 | ||
| Supplier’s Catalog No | 373954 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 64.7 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a liquid in Tris, 50% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Source: Recombinant protein corresponding to aa1-441 from bovine KRT17, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~64.7kD AA Sequence: MTTTIRHFSSGSIKGSSGLAGGSSRSCRVSGSLGGGSCRLGSAGGLGSGLGGSSYSSCYSFGSGGGYGSGGYVSGGYGGGFGGVDGLLVGGEKATMQNLNDRLASYLDKVRALEEANTELELKIRDWYQKQAPGPAPDYSSYFKTIEDLRNKIHTATVDNANLLLQIDNARLAADDFRTKFETEQALRVSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMKALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTLQALEIELQSQLSMKASLEGSLAETENRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKTKEPVTTRQVRTIVEEVQDGRVISSREQVHQTSH Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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