TIMP2, Recombinant, Human (Tissue Inhibitor of Metalloproteinases 2, TIMP-2, Metalloproteinase Inhibitor 2, CSC-21K, DDC8)
Catalog No : USB-149569
441.39€
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| Product name | TIMP2, Recombinant, Human (Tissue Inhibitor of Metalloproteinases 2, TIMP-2, Metalloproteinase Inhibitor 2, CSC-21K, DDC8) | ||
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| Catalog No | USB-149569 | ||
| Supplier’s Catalog No | 149569 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE and HPLC) | ||
| Form | Supplied as a lyophilized powder. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE and HPLC) | ||
| Description | TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8kD protein containing 194aa. Source: Recombinant protein corresponding to human TIMP-2, expressed in E. coli. Biological Activity: TIMP-2 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-2 concentration of approximately 0.5ug/ml, when using an MMP-1 concentration of 1.6ug/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: MCSCSPVHPQ QAFCNADVVI RAKAVSEKEV DSGNDIYGNP IKRIQYEIKQ IKMFKGPEKD IEFIYTAPSS AVCGVSLDVG GKKEYLIAGK AEGDGKMHIT LCDFIVPWDT LSTTQKKSLN HRYQMGCECK ITRCPMIPCY ISSPDECLWM DWVTEKNING HQAKFFACIK RSDGSCAWYR GAAPPKQEFL DIEDP Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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