Matrix Metalloproteinase 8, Recombinant, Human (MMP-8, Neutrophil Collagenase)
Catalog No : USB-209085
417.25€
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| Product name | Matrix Metalloproteinase 8, Recombinant, Human (MMP-8, Neutrophil Collagenase) | ||
|---|---|---|---|
| Catalog No | USB-209085 | ||
| Supplier’s Catalog No | 209085 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 75 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Purified | ||
| Purity | ~90% (SDS-PAGE). | ||
| Form | Supplied as a liquid in 0.05M Tris-HCl buffer, pH 7.5, 0.2M sodium chloride, 5mM calcium chloride, 20uM ZnSO4, 0.1% BSA. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE). | ||
| Description | Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation. Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes. Source: Recombinant protein corresponding to human MMP-8, a single, non-glycosylated, polypeptide chain, expressed in E. coli. Molecular Weight: ~75kD Biological Activity: ~100units/ml after activation with APMA by solution assay method (10U=100 assays). Unit Definition: One unit of collagenolytic activity is defined as the cleavage of 1ug of collagen/minute. Applications: Suitable for use as a standard for analyzing mammalian collagenase activity. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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