MMP3, Recombinant, Human (STMY1, Stromelysin-1, Matrix Metalloproteinase 3)
Catalog No : USB-215030
621.86€
0.00€
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| Product name | MMP3, Recombinant, Human (STMY1, Stromelysin-1, Matrix Metalloproteinase 3) | ||
|---|---|---|---|
| Catalog No | USB-215030 | ||
| Supplier’s Catalog No | 215030 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 42.8 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~98% (SDS-PAGE, HPLC) | ||
| Form | Supplied as a lyophilized powder in calcium chloride, CHAPS, sodium phosphate. No preservative added. Reconstitute with 100ul sterile ddH2O. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~98% (SDS-PAGE, HPLC) | ||
| Description | MMP-3 (matrix metalloproteinase 3), otherwise known as stromelysin-1, is a member of a family of secreted zinc-dependent endoproteases, which play a role in the degradation of extracellular matrix (ECM) components, including both fibrillar and non-fibrillar collagens, laminin, basement membrane glycoprotein and fibronectin. MMP-3 can degrade gelatins type I, III, IV, and V, type III, IV, IX and X collagens, as well as fibronectin, laminin, and cartilage proteoglycans. MMP-3 is implicated in wound repair, and tumor initiation, and studies have shown high expression of MMP-3 by monocytes, and that MMP-3 is also expressed by microglial cells, chondrocytes, and by fibroblast-like synoviocytes in patients with rheumatoid arthritis (RA) and osteoarthritis. Source: Recombinant protein corresponding to human MMP-3 expressed in E. coli. Molecular Weight: ~42.8kD (378aa) containing the entire catalytic N-terminal domain and the C-terminal domain. Activity: MMP-3 activity was measured by its ability to cleave a chromogenic peptide MMP-3 substrate at RT. At a MMP-3 concentration of ~2.5ug/ml, 50% cleavage was achieved at an incubation time of ~75 mins. Applications: Suitable for use in Functional Assays. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Endotoxin Level: <1EU/ug Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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