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Categories: Peptides & Proteins / Proteins

Product name			TACE, Recombinant, Human (Snake Venom-like Protease, TNF-alpha Convertase, ADAM17, TNF-alpha-converting Enzyme, CD156b)
Catalog No			USB-220300
Supplier’s Catalog No			220300
Supplier			US Biologicals
Source antigen			Recombinant, Insect cell
Reactivity
Cross reactivity
Applications
Molecular weight			62

Storage			-70°C
Other names
Grade			Purified
Purity			~90% (SDS-PAGE)
Form			Supplied as a lyophilized powder. Reconstitute with sterile ddH2O to 0.1ug protein/ul.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~90% (SDS-PAGE)
Description			TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) family of proteins. It cleaves 26kD type II membrane-bound precursor of TNF-a into 17kD mature form which is secreted. TACE is also known to process other membrane proteins including TNF receptor, TGF-alpha and amyloid protein precursor. Recombinant active untagged TACE amino acid sequence is from Arg215 to Asn651. The apparent molecular weight is bigger than the calculated MW due to the protein posttranslational modification in eukaryotic system. Source: Recombinant protein corresponding to human TACE, expressed in Insect cells. Molecular Weight: ~62kD Biological Activity: Tested using the synthetic peptide, Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa(Dnp)-NH2, as a substrate. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.