Matrix Metalloproteinase 3, Recombinant, Human, His-Tag (MMP3, Stromelysin-1, Transin-1)
Catalog No : USB-299449
419.55€
0.00€
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| Product name | Matrix Metalloproteinase 3, Recombinant, Human, His-Tag (MMP3, Stromelysin-1, Transin-1) | ||
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| Catalog No | USB-299449 | ||
| Supplier’s Catalog No | 299449 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, HEK293 cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 52 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in Tris, sodium chloride, Brij35. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | MMP-3 enzyme is also known as Stromelysin-1 or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk. MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta. Source: Recombinant protein corresponding to a proform of the human MMP3 [Tyr18-Cys477 (Lys45Glu)], fused to His-tag at C-terminal, expressed in HEK293 cells. Molecular Weight: ~52kD Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >150 pmoles/min/ug Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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