MHC class I polypeptide-related sequence A, active (MICA), Recombinant, Human
Catalog No : USB-348175
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| Product name | MHC class I polypeptide-related sequence A, active (MICA), Recombinant, Human | ||
|---|---|---|---|
| Catalog No | USB-348175 | ||
| Supplier’s Catalog No | 348175 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Human, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 36.9 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ≥95% as determined by SDS-PAGE and HPLC. | ||
| Form | Lyophilized from 0.2um filtered 30% Acetonitrile, 0.1% TFA | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥95% as determined by SDS-PAGE and HPLC. | ||
| Description | Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}. Biological Activity: Fully biologically active when compared to standard. The specific activity is determined by binding MICA antibody in ELISA. Sequence: MSYYHHHHHH DYDIPTTENL YFQGAMAPEF EPHSLRYNLT VLSWDGSVQS GFLTEVHLDG QPFLRCDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETKEWTMP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLKSGVVLRR TVPPMVNVTR SEASEGNITV TCRASGFYPW NITLSWRQDG VSLSHDTQQW GDVLPDGNGT YQTWVATRIC QGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSH KLGCFGG Molecular Weight: 36.9kD PubMed ID: 8022771; 8613147; 14574404; 15489334; 7927538; 8781120; 10e331160; 10e380703; 10e369920; 15104678; 10e380704; 11556982; 11841487; 10746789; 12074712; 16634869; 10e369917; 12542746; 8901601; 9396860; 9497295; 10e323458; 10e363723; 10e359807; 10426993; 10426994; 10691930; 11053635; 11777960; 19793804; 10752636; 11485740; 11491531; 11224526; 12466900; 12370336; 12384702; 11830641; 12902493; 15995699; 16750166; 17495932; 17565371; 18287244; 18202175; 10e367903; 11323699 Gene Name: MICA, PERB11.1 Swiss Prot: Q29983 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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