Monocarboxylate Transporter 4, Rat, Control Peptide (MCT4)
Catalog No : USB-M4470-29C
417.25€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | Monocarboxylate Transporter 4, Rat, Control Peptide (MCT4) | ||
|---|---|---|---|
| Catalog No | USB-M4470-29C | ||
| Supplier’s Catalog No | M4470-29C | ||
| Supplier | US Biologicals | ||
| Source antigen | Rat synthetic peptide | ||
| Reactivity | 100% conserved in mouse, human and 78% in chicken. No significant sequence homology exists with other MCTs. Control peptide, because of its low MW (<3kD), is not suitable for Western. It should be used for ELISA or antibody blocking to confirm antibody specificity | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied as a liquid in PBS, pH 7.2 | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | A 19-aa peptide sequence within the cytoplasmic, C-terminus of rat/mouse/human MCT4. Monocarboxylate such as lactate and pyruvate play an important role in cellular metabolism. Lactic acid is produced as the end product of glycolysis. Some tissues, such as white skeletal muscle and, red blood cells, use this pathway to generate most of their ATP under normal physiological conditions. All tissues become dependent on this pathway during abnormal conditions such as hypoxia and ischaemia. Lactic acid, produced during normal glycolysis, must be transported out of cells to sustain maintain high rate of glycolysis. Failure to export lactic acid leads to accumulation of cellular lactic acid followed by an increase in pH and inhibition of glycolysis. Some tissues, such as brain, heart, and red skeletal muscle, readily oxidize lactic acid, and must import lactic acid into the cells. Lactic acid transport is mediated by a group of proton-linked membrane transporters called monocarboxylic acid transporters (MCTs). At least 9 MCT-related proteins (MCT1-9) have been identified in mammals that are expressed in a tissue specific manner. MCT4/MOT4/SLC16A3 (mouse 470-aa, rat 471-aa, human 465-aa; chromosome 17q25) is most closely related to MCT3, is prominently expressed in skeletal muscle and other cells with a high glycolytic rate such as tumor cells and white blood cells, suggesting an important role in lactic acid efflux. According to new nomenclature, the old MCT3 has now been reclassified as MCT4. This antibody has previously been listed as MCT31-S. Please consult the main MCT page for details on the new nomenclature. | ||
Product Details
© 2020 Imugex All Rights Reserved