Netrin-1,Fc, Recombinant, Human (NTN1)

Catalog No : USB-045078
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Product name Netrin-1,Fc, Recombinant, Human (NTN1)
Catalog No USB-045078
Supplier’s Catalog No 045078
Supplier US Biologicals
Source antigen Recombinant, Human, HEK 293 cells
Reactivity Binds to human, mouse and rat UNC5B.
Cross reactivity
Applications
Molecular weight 90
Storage 4°C/-20°C
Other names
Grade Highly Purified
Purity >95% (SDS-PAGE)
Form Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2, with trehalose and Brij35.
Reactivity life 6 months
Note For reserch purpose only
Purity >95% (SDS-PAGE)
Description Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis. Biological Activity: Induces axon outgrowth. Sequence: Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.