Visinin-like protein-1, Recombinant Human (VSNL1, VILIP-1)
Catalog No : USB-V2124-26
456.33€
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| Product name | Visinin-like protein-1, Recombinant Human (VSNL1, VILIP-1) | ||
|---|---|---|---|
| Catalog No | USB-V2124-26 | ||
| Supplier’s Catalog No | V2124-26 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E.coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 22.1 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Affinity Purified | ||
| Purity | ~95 % by SDS-PAGE Purified by immunoaffinity chromatography. Endotoxin: ≤1.0EU/ug (LAL) | ||
| Form | Supplied as liquid in 20mM Tris-HCl buffer, pH8.0, 1mM DTT, 10% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95 % by SDS-PAGE Purified by immunoaffinity chromatography. Endotoxin: ≤1.0EU/ug (LAL) | ||
| Description | Visinin-like protein-1, also known as VILIP-1, belongs to a family of neuronal calcium sensor proteins. VILIP-1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Also, it is expressed in pancreatic beta-cells. VILIP-1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. Recombinant human Visinin-like protein-1 , expressed in E. coli and purified by using conventional chromatography. Recombinant protein corresponding to aa1-191 of human Visinin-like protein-1 expressed in E. coli (NP_003376) Amino Acid Sequence: MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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