BIN1, Recombinant, Human (Amphiphysin II, AMPHL, Box-dependent Myc-interacting Protein 1, Bridging Integrator 1, Myc Box-dependent-interacting Protein 1, Amphiphysin-like Protein)
Catalog No : USB-B1200-02
508.06€
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| Product name | BIN1, Recombinant, Human (Amphiphysin II, AMPHL, Box-dependent Myc-interacting Protein 1, Bridging Integrator 1, Myc Box-dependent-interacting Protein 1, Amphiphysin-like Protein) | ||
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| Catalog No | USB-B1200-02 | ||
| Supplier’s Catalog No | B1200-02 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E.coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 50.4 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Affinity Purified | ||
| Purity | ~90% (SDS-PAGE). | ||
| Form | Supplied as a liquid in 20mM Tris, pH 8.0, 10% glycerol, 1mM DTT. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE). | ||
| Description | BIN1, also known as SH3P9, is a nucleocytoplasmic adaptor protein, one of which was initially identified as MYC-interacting protein with features of a tumor suppressor. This protein interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Source: Recombinant corresponding to aa1-439 of human BIN1 protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKAEEELIK AQKVFEEMNV DLQEELPSLW NSRVGFYVNT FQSIAGLEEN FHKEMSKLNQ NLNDVLVGLE KQHGSNTFTV KAQPSDNAPA KGNKSPSPPD GSPAATPEIR VNHEPEPAGG ATPGATLPKS PSQPAEASEV AGGTQPAAGA QEPGETAASE AASSSLPAVV VETFPATVNG TVEGGSGAGR LDLPPGFMFK VQAQHDYTAT DTDELQLRAG DVVLVIPFQN PEEQDEGWLM GVKESDWNQH KELEKCRGVF PENFTERVP Molecular Weight: 50.4kD (459aa) confirmed by MALDI-TOF Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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