Amylin, Recombinant, Human (DAP, IAP, Islet Amyloid Polypeptide, Diabetes-associated Peptide, Insulinoma Amyloid Peptide, IAPP)
Catalog No : USB-208741
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| Product name | Amylin, Recombinant, Human (DAP, IAP, Islet Amyloid Polypeptide, Diabetes-associated Peptide, Insulinoma Amyloid Peptide, IAPP) | ||
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| Catalog No | USB-208741 | ||
| Supplier’s Catalog No | 208741 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 3.9 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (RP-HPLC, SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in 1% acetic acid. No preservative added. Reconstitute with 1% acetic acid. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (RP-HPLC, SDS-PAGE) | ||
| Description | Amylin, or Islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly 100:1 ratio). Amylin functions as part of the endocrine pancreas and contributes to glycemic control. Although amylin's complete function may not yet be known, it has been shown to slow gastric emptying, promote satiety, inhibit secretion of glucagon during hyperglycemia, and therein reduce the total insulin demand. As insulin lowers blood glucose and glucagon raises blood glucose, amylin supports the stability of blood glucose levels in effect by slowing the rate that digested glucose enters the bloodstream. Rodent amylin knockouts are known to fail to achieve the normal anorexia following food consumption. Because it is an amidated peptide, like many neuropeptides, it is believed to be responsible for the anorectic effect. It was identified independently by two groups as the major component of islet Amyloid deposits in 1987 (Cooper et al and Westermark et al). There appears to be at least three distinct receptor complexes that bind with high affinity to amylin. All three complexes contain the calcitonin receptorat the core, plus one of three Receptor activity-modifying proteins, RAMP1, RAMP2, or RAMP3. Source: Recombinant protein corresponding to human Amylin, a non-glycosylated, polypeptide chain containing 37aa, expressed in E. coli. Molecular Weight: ~3.90kD AA Sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (37aa) Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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