NT-1, Recombinant, Human (Neurotrophin 1/B Cell Stimulating Factor 3, BCSF-3)
Catalog No : USB-N5399
354.03€
0.00€
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| Product name | NT-1, Recombinant, Human (Neurotrophin 1/B Cell Stimulating Factor 3, BCSF-3) | ||
|---|---|---|---|
| Catalog No | USB-N5399 | ||
| Supplier’s Catalog No | N5399 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ≥ 98% by SDS-PAGE and HPLC analyses | ||
| Form | Supplied as a lyophilized powder | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥ 98% by SDS-PAGE and HPLC analyses | ||
| Description | Human NT-1/BCSF-3 (Neurotrophin-1/B-Cell Stimulating Factor-3) is identified as part of the IL-6 family of cytokines. It is most homologous to cardiotrophin-1 and ciliary neurotrophic factor. NT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-b) and induces tyrosine phosphorylation of these receptors. In vitro, it supports survival of chick embryo motor and sympathetic neurons. In mice, NT-1/BCSF-3 includes serum amyloid A, causes body weight loss and B cell hyperplasia associated with increase in serum IgG and IgM. Recombinant human NT-1/BCSF-3 is a 22.4kD protein containing 199 amino acid residues. AA Sequence: MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF Endotoxin: ≤ 0.1ng/ug (1EU/ug) Biological Activity: NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0ng/ml. Reconstitution: Reconsitute with water to a concentration of 0.1-1.0mg/ml. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile water and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Country of Origin: USA | ||
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