NT-4, Recombinant, Human, Animal Free (Neurotrophin-4, Neurotrophic 4/5, NT-4/NT-5)
Catalog No : USB-208682
359.78€
0.00€
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| Product name | NT-4, Recombinant, Human, Animal Free (Neurotrophin-4, Neurotrophic 4/5, NT-4/NT-5) | ||
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| Catalog No | USB-208682 | ||
| Supplier’s Catalog No | 208682 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~98% (SDS-PAGE gel, HPLC) | ||
| Form | Supplied as a lyophilized powder. No additives. Reconstitute with ddH2O. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~98% (SDS-PAGE gel, HPLC) | ||
| Description | Neurotrophin-4 (NT-4/NT-5) is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. NT-4 is a neurotrophic factor structurally related to beta-NGF, BDNF and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. The active form of human NT-4 is a dimer, formed by two identical 130 amino acid subunits, which is held together by strong hydrophobic interactions. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0kD polypeptide monomers (260 total amino acid residues). Source: Recombinant protein corresponding to human NT-4 expressed in E. coli. Biological Activity: The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50ng/ml. Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA Protein Content: Verified by UV Spectroscopy and/or SDS-PAGE gel. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with H2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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