NOS I, Human (Nitric Oxide Synthase 1, bNOSn, NOS-1) Control Peptide
Catalog No : USB-N5350-07
417.25€
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| Product name | NOS I, Human (Nitric Oxide Synthase 1, bNOSn, NOS-1) Control Peptide | ||
|---|---|---|---|
| Catalog No | USB-N5350-07 | ||
| Supplier’s Catalog No | N5350-07 | ||
| Supplier | US Biologicals | ||
| Source antigen | Human synthetic peptide | ||
| Reactivity | Rat peptide sequence is 95% conserved in mouse, human and rabbit | ||
| Cross reactivity | Human, Mouse, Rabbit, Rat | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied in SDS-PAGE sample buffer | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | Human, rat, and mouse bNOS/NOS-1 are 1433 aa, 1429 aa, and 1429 aa proteins respectively. Nitric oxide (NO), a diffusible free radical gas, acts as a neurotransmitter in brain and peripheral nervous system. It accounts for the activity of endothelium-derived relaxing factors, which stimulate vasodilatation by releasing NO from the endothelium. Unlike typical neurotransmitter, NO is a not stored in synaptic vesicle and does not act on membrane receptors. Synthesis of NO, initially demonstrated in vascular endothelium, is now found in many tissues. NO is synthesized by L-arginine, oxygen, and NADPH by three known isoforms of heme-containing flavoproteins termed NO synthase (NOS, I-III, mol wt. ~130-160kD). One group of enzyme is constitutive, agonist-triggered, and dependent on Ca2+/Calmodulin and is inhibited by L-arginine analogues (L-NNA, L-NMMA). It is found in endothelium, adrenal glands, brain and platelets. The other principle group is inducible, Ca2+/Calmodulin-independent, and inhibited by NMMA and L-NNA. It has been found in macrophage, hepatocytes, tumor cells, vascular smooth muscle and endothelial cells. Analyses of cDNA clones have identified three distinct NOS genes in mammals: neuronal (nNOS/bNOS/NOS-I), endothelial (eNOS/NOS-III), and macrophage (mNOS/iNOS/NOS-II). Both nNOS and eNOS are constitutive and the mNOS/iNOS is inducible. Sequence homology among different cloned isoforms is ~ 50%. | ||
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