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Categories: Peptides & Proteins / Proteins

Product name			DLL4, Recombinant, Mouse,Fc (Delta-like Protein 4, Delta4)
Catalog No			USB-044755
Supplier’s Catalog No			044755
Supplier			US Biologicals
Source antigen			Recombinant, HEK 293 cells
Reactivity
Cross reactivity
Applications
Molecular weight			95

Storage			-20°C
Other names
Grade			Highly Purified
Purity			≥90% (SDS-PAGE). Endotoxin: ≤0.1EU/ug (LAL method)
Form			Supplied as a liquid PBS, pH 7.2.
Reactivity life			6 months
Note			For reserch purpose only
Purity			≥90% (SDS-PAGE). Endotoxin: ≤0.1EU/ug (LAL method)
Description			The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina. Biological Activity: Inhibits adipogenesis of 3T3L-1 cells. Sequence: Signal peptide and extracellular domain of mouse DLL4 (aa 1-532) is fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.